Annals of Applied Physiology

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Tayebi S M, Krüger K. Cancer and Ras/Raf/ERK Pathway: The Role of New Regulators in Response to Physical Activity, Exercise, and Training. ANN. APPL. PHYSIOL. 2024; 1 : 2
URL: http://aapjournal.com/article-1-22-en.html

Background. Cancer is the second and most common cause of death in developed countries, and epidemiological evidence suggests a similar trend in developing countries. Cancer currently causes twelve percent of all deaths worldwide. The ERK pathway contains important modulators suitable for growth and proliferation, especially tumors. Oxidative stress, growth factors, intracellular increases in calcium levels, and stimulation of glutamate receptors activate this pathway. The Sprouty/Spred family acts as definitive negative regulators of the Ras/Raf/ERK signal.
View Points. The Sprouty/Spred family plays a crucial role in cancer research by specifically inhibiting ERK activity in response to a wide range of factors such as fibroblast growth factor (FGF), platelet growth factor (PDGF), vascular endothelial growth factor (VEGF), brain-derived neurotrophic factor (BDNF), nerve growth factor (NGF), and glial cell-derived growth factor (GDNF). This family's ability to inhibit MAPK activity and affect the downstream level is a crucial aspect of their function. Typically, these proteins inhibit growth by modulating RTK signaling and suppressing the MAPK_ERK signaling pathway, thereby suppressing cell proliferation, migration, and differentiation.
Objectives. Research on the effect of exercise at various levels on the Sperouty/Spred family in inactive healthy individuals and patients, especially in cancer situations, has not been performed. So, future research can be directed in this way.