en Biochemistry and Metabolism مقاله اصیل Original Article <div style="text-align: justify;"><strong>Background.</strong> Adipokines play a significant role in autocrine/paracrine regulation of adipocyte differentiation, metabolism, and local inflammatory responses. They also regulate the systemic metabolism of fat and glucose through the intracellular/systemic action of the brain, liver, and muscle. Semaphorin 3E (Sema3E) is a novel adipokine essential to obesity and related diseases. Sema3E is an exception among semaphorin proteins and depends on a specific Plexin D1 receptor (Plexin D1).<br> <strong>Objectives. </strong>This brief review synthesizes the current knowledge dealing with the role that Sema3E and Plexin D1 can play in response to physical exercise effects in individuals with obesity.<br> <strong>Methods. </strong>A brief narrative review is used to reach the aim of the study.<br> <strong>Results. </strong>Some scientific evidence may suggest a positive influence of physical exercise training on Semaphorin 3E/Plexin D1 Axis levels.<br> <strong>Conclusions.</strong> However, physical exercise has a role in these factors that must be investigated to improve our understanding of the role of inflammation in obesity and insulin resistance.</div> Obesity, Adipokines, Semaphorins, Adipocyte Cytokines, Physical Activity 0 0 http://aapjournal.com/browse.php?a_code=A-10-1-2&slc_lang=en&sid=1 Arash Khodamoradi arash.khodamoradi@yahoo.com 100319475328460088 100319475328460088 Yes Department of Biological Sciences in Sport, Faculty of Sports Sciences and Health, Shahid Beheshti University, Tehran, Iran Abedin Khosravi Khosravi@gmail.com 100319475328460089 100319475328460089 No Department of Physical Education and Sport Science, Payame Noor University, Iran Patricia K. Doyle-Baker pdoyleba@ucalgary.ca 100319475328460090 100319475328460090 No Human Performance Lab, Faculty of Kinesiology, University of Calgary, Alberta, Canada Abderraouf Ben Abderrahman abderraouf.benabderrahman@issep.uma.tn 100319475328460091 100319475328460091 No Higher Institute of Sport and Physical Education of Ksar-Said, University of Manouba, Cité Nasr, Tunisia Eugenia Murawska-Ciałowicz eugenia.murawska-cialowicz@awf.wroc.pl 100319475328460092 100319475328460092 No University School of Physical Education, Physiology and Biochemistry Department, Wrocław, Poland Anthony C. Hackney thackney@med.unc.edu 100319475328460093 100319475328460093 No Department of Exercise & Sport Science, University of North Carolina, Chapel Hill, NC, USA Kelly E. Johnson 100319475328460094 100319475328460094 No Department Kinesiology, Coastal Carolina University, Conway, SC, USA Ayoub Saeidi saeidi_as68@yahoo.com 100319475328460095 100319475328460095 No Department of Physical Education and Sport Sciences, Faculty of Humanities and Social Sciences, University of Kurdistan, Sanandaj, Iran